Selected Publications

For a full list of lab publications click here

Coles CH^, Shen Y^, Tenney AP, Siebold C, Sutton GC, Lu W, Gallagher JT, Jones EY*, Flanagan JG*, Aricescu AR* (2011) Proteoglycan-specific molecular switch for RPTPsigma clustering and neuronal extension. Science 332:484-8. [^co-first, *co-corresponding] 

Hancock ML, Nowakowski DW, Role LW, Talmage DA*, Flanagan JG* (2011) Type III Neuregulin 1 regulates pathfinding of sensory axons in the developing spinal cord and periphery. Development 138:4887-98. [*co-corresponding] 

Tcherkezian, J*, Brittis, PA*, Thomas, F, Roux, PP, Flanagan, JG (2010) Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation. Cell 141:632-44. [*co-first] 

Shen, Y*, Tenney, AP*, Busch, SA, Horn, KP, Cuascut, FX, Liu, K, He, Z, Silver, J, Flanagan JG.  (2009) PTPsigma is a receptor for chondroitin sulfate proteoglycan, an inhibitor of neural regeneration. Science 326:592-6.  [*co-first]  

Chen, Y, Mohammadi, M, Flanagan, JG (2009) Graded levels of FGF protein span the midbrain and can instruct graded induction and repression of neural mapping labels. Neuron 62:773-780. 

Osterfield, M, Egelund, R, Young, LM, and Flanagan, JG (2008) Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system. Development 135:1189-99.

Flanagan, JG. (2006) Neural map specification by gradients. Curr. Op. Neurobiol. 16:59-66.

Hansen, MJ, Dallal, GE, Flanagan, JG. (2004) Retinal axon response to A ephrins shows a graded, concentration-dependent transition from growth promotion to inhibition.  Neuron 42:717-730.

Osterfield, M, Kirschner, MW, and Flanagan, JG. (2003)  Graded positional information: interpretation for both fate and guidance. Cell 113: 425-428.

Brittis, PA, Lu, Q, and Flanagan, JG. (2002) Axonal protein synthesis provides a mechanism for localized regulation at an intermediate target. Cell 110:223-235.

Lu, Q, Sun, EE, Klein, RS, and Flanagan, JG (2001) Ephrin-B reverse signaling is mediated by a novel PDZ-RGS protein and selectively inhibits G-protein coupled chemoattraction. Cell 105:69-79.

Flanagan, JG, Cheng, H-J (2000) Alkaline phosphatase fusion proteins for molecular characterization and cloning of receptors and their ligands. Meth. Enzymol. 327: 198-210.

Hattori, M, Osterfield, M, and Flanagan, JG (2000) Regulated cleavage of a contact mediated axon repellent. Science 289: 1360-1365.

Vanderhaeghen, P, Lu, Q, Prakash, N, Frisen, J, Walsh, CA, Frostig, RD, Flanagan, JG (2000) A mapping label required for normal scale of the body representation in the cortex. Nature Neuroscience 3: 358-65.

Nakamoto, M, Cheng, H-J, Friedman, GC, McLaughlin, T, Hansen, M, Yoon, C, O'Leary, DDM, Flanagan, JG (1996) Topographically specific effects of ELF-1 on retinal axon guidance in vitro and retinal axon mapping in vivo. Cell 86: 755-66.

Cheng, H-J, Nakamoto, M, Bergemann, AD, Flanagan, JG (1995) Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map.  Cell 82: 371-81.

Cheng H-J, Flanagan JG (1994) Identification and cloning of ELF-1, a developmentally-expressed ligand for the Mek4 and Sek receptor tyrosine kinases.  Cell 79:157-68.